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SAFE TRIPS

Collaborators: ANZIC-RC; the George Institute for International Health. Endorsed by the ANZICS CTG

Summary

To determine fluid resuscitation practices around the world following the publication of the SAFE study.  The study will be conducted two phases –

Phase 1

To describe annual per-capita albumin use in Australia and New Zealand and internationally in the period from January 1995 to December 2005.  We will assess changes in albumin use in response publication of the Cochrane Review (1998) and the SAFE study paper (2004).  A manuscript has been prepared for submission.

Phase 2

An inception cohort study to determine fluid resuscitation practices around the world following the publication of the SAFE study to assess the extent of translation of research into practice (TRIP). We will use a simplified SAFE Study CRF to collect a minimum critical data set at ICU admission and during a single 24-hour period.  The aims of the study are to

  1. document current practice in fluid resuscitation
  2. determine if there are identifiable patient characteristics that influence choice of fluid
  3. determine whether there are identifiable regional or national variations in choice of resuscitation fluid that are not explained by patient characteristics

Outcome data will be limited to ICU and hospital mortality censored at 28 days. A total of 519 sites from 25 countries participated in the study which occurred on three individual days in April, May and June 2007 .

Principal Investigators